GPR37 Antibody - BSA Free

Immunohistochemistry-Paraffin: GPR37 Antibody [NLS131] - Brain, Thalamus, neuron

Immunohistochemistry-Paraffin: GPR37 Antibody [NLS131] - Analysis of anti-GPR37 antibody with human brain, neurons and glia.

Immunohistochemistry-Paraffin: GPR37 Antibody [NLS131] - Anti-PAEL Receptor / GPR37 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: GPR37 Antibody [NLS131] - Anti-PAEL Receptor / GPR37 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: GPR37 Antibody [NLS131] - Anti-PAEL Receptor / GPR37 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: GPR37 Antibody [NLS131] - Anti-PAEL Receptor / GPR37 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

• Reactivity: Hu, Pm
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

GPR37 Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 20 amino acid peptide from N-terminal extracellular domain of human GPR37.
• Epitope: N-Terminus extracellular domain
• Specificity: Human GPR37. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Primate (95%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GPR37
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 6 - 11 ug/ml
• Application Notes: .

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (95%), Gibbon (95%), Marmoset (90%), Rabbit (85%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for GPR37 Antibody - BSA Free

• EDNRBL
• Endothelin B receptor-like protein 1
• ETBR-LP-1
• G protein-coupled receptor 37 (endothelin receptor type B-like)
• GPR37
• hET(B)R-LP
• PAELR
• PAELRETBR-LP-1
• Parkin-associated endothelin receptor-like receptor
• probable G-protein coupled receptor 37

Background

GPR37 is an Orphan-A GPCR with an unknown ligand. GPR37 was recently identified as the PAEL receptor, a Parkin substrate involved in autosomal recessive juvenile Parkinson's (PDJ) disease. The PAEL receptor becomes unfolded, insoluble, and ubiquitinated when overexpressed, leading to unfolded protein-induced cell death. When the PAEL receptor is ubiquitinated by Parkin, it gets degraded, resulting in the suppression of cell death. The insoluble form of the PAEL receptor accumulates in the brains of PDJ patients and may cause selective neuronal death. GPR37 expression has been reported in brain, liver, and placenta. ESTs have been isolated from brain, embryo, eye, fetal lung/testis/Bcell, gallbladder, heart, liver, liver/spleen, melanocyte/uterus/fetal heart, nerve, placenta, testis, tonsil, and vessel libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GPR37
• Entrez:
  • 2861(Human)