GPR37 Products

Description

GPR37 is an Orphan-A GPCR with an unknown ligand. GPR37 was recently identified as the PAEL receptor, a Parkin substrate involved in autosomal recessive juvenile Parkinson's (PDJ) disease. The PAEL receptor becomes unfolded, insoluble, and ubiquitinated when overexpressed, leading to unfolded protein-induced cell death. When the PAEL receptor is ubiquitinated by Parkin, it gets degraded, resulting in the suppression of cell death. The insoluble form of the PAEL receptor accumulates in the brains of PDJ patients and may cause selective neuronal death. GPR37 expression has been reported in brain, liver, and placenta. ESTs have been isolated from brain, embryo, eye, fetal lung/testis/Bcell, gallbladder, heart, liver, liver/spleen, melanocyte/uterus/fetal heart, nerve, placenta, testis, tonsil, and vessel libraries.

Bioinformatics

Entrez	2861 Human
Uniprot	NP_005293.1 Human O15354 Human
Product By Gene ID	2861
Alternate Names	EDNRBL Endothelin B receptor-like protein 1 G protein-coupled receptor 37 (endothelin receptor type B-like) hET(B)R-LP PAELRETBR-LP-1 Parkin-associated endothelin receptor-like receptor probable G-protein coupled receptor 37

Research Areas for GPR37

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GPCR