GPR158 Antibody (1027651) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 1027651
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

GPR158 Antibody (1027651) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human GPR158 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GPR158 Antibody (1027651) [Alexa Fluor™ Plus 647]

• G protein-coupled receptor 158
• GPR158
• KIAA1136
• KIAA1136FLJ37801
• probable G-protein coupled receptor 158
• RP11-59G22.1

Background

G-protein coupled receptor 158 (GPR158) is a receptor belonging to the Class C GPCR family. It lacks the extracellular Venus flytrap module characteristic of the known members of that family and instead contains two other elements that are not typical of the class: a calcium-binding EGF-like domain and a leucine repeat region (1, 2). The mature extracellular domain of human GPR158 contains 393 amino acids (aa) and shares 89% identity with both mouse and rat GPR158. GPR158 is expressed at the highest level in the brain, but also in a variety of other tissues including retina, spleen, liver and lung (3). GPR158 was originally identified in functional screens linked with biological stress and has been implicated in the osteocalcin effect on cognitive processes in the brain (4, 5), and glaucoma and cancer in the periphery (4, 6).

1. Jingami, H. et al. (2003) Curr. Opin. Neurobiol. 13:271.
2. Bjarnadóttir, T.K et al. (2005) Gene. 362:70.
3. Orlandi, C. et al. (2012) J. Cell Biol. 197:711.
4. Itakura, T. et al. (2019) J. Ocul. Pharmacol. Ther. 35:203.
5. Khrimian, L. et al. (2017) J. Exp. Med. 214:2859.
6. Fenner, A. (2015) Nat. Rev. Urol. 12:182.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.