Glycine Receptor Alpha 1 Antibody

Staining of human cell line HEL shows localization to plasma membrane & vesicles.

Product Discontinued

Glycine Receptor Alpha 1 Antibody Summary

• Immunogen: This antibody has been engineered to specifically recognize the recombinant protein Glycine Receptor Alpha 1 using the following amino acid sequence: CTKHYNTGKFTCIEARFHLERQMGY
• Predicted Species: Mouse (100%), Rat (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GLRA1
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 0.25-2 µg/ml
• Application Notes: For ICC/IF, we recommend using a combination of PFA and Triton X-100. This will give you the optimal results for your experiments.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS, pH 7.2, 40% glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for Glycine Receptor Alpha 1 Antibody

• GLRA 1
• GLRA1
• Glycine receptor 48 kDa subunit
• Glycine receptor strychnine-binding subunit
• glycine receptor subunit alpha-1
• glycine receptor, alpha 1 (startle disease/hyperekplexia)
• glycine receptor, alpha 1
• HKPX1
• MGC138878
• MGC138879
• STHE

Background

Glycine is an important inhibitory neurotransmitter in the mammalian central nervous system, especially in the brainstem and spinal cord. It acts by binding to anion-conducting glycine receptors that belong to a superfamily of ligand-gated ion channels. Glycine receptors were first purified as strychnine binding sites in membrane fractions of adult spinal cord from rats (1). These strychnine-sensitive binding sites are different from the strychnine-insensitive binding sites found in the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors. Adult glycine receptors are heterodimers composed of two subunits of 48 kDa and 58 kDa, denoted as a1 and b subunits. Fetal glycine receptors are homomers composed of a2 subunits.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GLRA1