Recombinant Human Glutathione Peroxidase 4/GPX4 Protein

Product Discontinued

Recombinant Human Glutathione Peroxidase 4/GPX4 Protein Summary

• Description: Partial recombinant protein corresponding to the amino acids 25- 197 of Human GPX4
  
  

  Source: Escherichia coli

  Amino Acid Sequence:P36969

• Source: E. coli
• Protein/Peptide Type: Recombinant Protein
• Gene: GPX4
• Purity: >95%, by SDS-PAGE

Applications/Dilutions

• Dilutions:
  • SDS-Page
• Theoretical MW: 19 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: 20 mM Hepes, pH 7.4.
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: >95%, by SDS-PAGE
• Reconstitution Instructions: Reconstitute with distilled water.

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Recombinant Human Glutathione Peroxidase 4/GPX4 Protein

• EC 1.11.1
• EC 1.11.1.12
• glutathione peroxidase 4 (phospholipid hydroperoxidase)
• Glutathione Peroxidase 4
• GPX4
• GPx-4
• GSHPx-4
• MCSP
• PHGPx
• PHGPxsnGPx
• phospholipid hydroperoxidase
• phospholipid hydroperoxide glutathione peroxidase, mitochondrial
• snGPx
• snPHGPx
• sperm nucleus glutathione peroxidase

Background

Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, experimental evidence for alternative splicing exists; alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

FAQs for Glutathione Peroxidase 4/GPX4 Recombinant Protein (P4548). (Showing 1 - 1 of 1 FAQ).

1. Is the Glutathione Peroxidase/GPX4 recombinant protein (Catalog # P4548) catalytically active (i.e., can it be used for functional enzyme assays)?
   • I have checked the data we have available for the Glutathione Peroxidase 4 protein P4548 and it seems that this protein has not been verified for biological activity.

Bioinformatics

• Gene Symbol: GPX4