Glutaredoxin 1/GLRX1 Antibody [DyLight 405]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bv, Rb, ZeSpecies Glossary
Applications WB, ICC/IF (-)
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 405

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Catalog# & Conjugate Size Price

Glutaredoxin 1/GLRX1 Antibody [DyLight 405] Summary

Immunogen
Synthetic peptide made to an internal portion of human Glutaredoxin 1 (within residues 40-100). [Swiss-Prot# P35754]
Localization
Cytoplasm.
Predicted Species
Mouse (100%), Rat (100%), Porcine (100%), Bovine (100%), Rabbit (100%), Zebrafish (91%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GLRX
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/ml
Application Notes
This Glutaredoxin 1 antibody is useful for Western blot where a band is seen ~14 kDa. This antibody is not useful for ICC/IF.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
14 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human. Predicted to react with mouse, rat, rabbit, porcine, bovine based on 100% sequence homology. Immunogen sequence has 91% homology to Zebrafish.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Glutaredoxin 1/GLRX1 Antibody [DyLight 405]

  • GLRX
  • glutaredoxin (thioltransferase)
  • Glutaredoxin 1
  • glutaredoxin-1
  • GRXGRX1
  • MGC117407
  • Thioltransferase
  • thioltransferase-1
  • TTase-1

Background

Glutaredoxins (GRXs) are one of thioredoxin superfamily members of thiol/disulfide exchange catalysts, and hence known as thioltransferases serving as reductants of protein SG mixed disulfides providing reducing equivalents to ribonucleotide reductase. Among two mammalian GRXs, GRX1 (Glutaredoxin 1) localizes in the cytosol primarily to mitochondria and to lesser extent in nucleus, whereas GRX2 has nuclear as well as mitochondrial isoforms. GRX1 is a relatively abundant, small ~12 kD cytosolic enzyme that regulates protein mixed disulfides through their reduction by GSH (S-glutathiolated proteins; R-SSG) and its functions depends upon GSH presence. When GRX1 deglutathionylates an S-glutathionylated substrate, a GRX1-SSG intermediate complex is formed, and the free GSH/glutathione reductase (GR) reduces the intermediate complex with NADPH to NADP+ and "reload" GRX1 to continue the catalysis. Unlike thioredoxin 1, GRX1 does not catalyze the reduction of sulfenic acid or intra-/inter-molecular disulfides, thereby efficiently catalyzing the reduction of R-SSG in the presence of NADPH and GR. Glrx1 is upregulated by several cytokines including IL-4, IL-6, IL-13 etc. and its expression is decreased by TGF-beta1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol GLRX
Entrez