FYCO1 Antibody

Product Discontinued

FYCO1 Antibody Summary

• Immunogen: FYCO1 (AAH07218, 1 a.a. ~ 256 a.a) full length recombinant protein with GST tag.MNTKVTSDWYYARSPFLQPKLSSDIVGQLYELTEVQFDLASRGFDLDAAWPTFARRTLTTGSSAYLWKPPSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLQERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQALELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMALHVGD
• Specificity: FYCO1 - FYVE and coiled-coil domain containing 1
• Clonality: Polyclonal
• Host: Mouse
• Gene: FYCO1
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot 1:500
• Application Notes: The quality control of this antibody is limited to Western blot on the immunizing protein. It has also been used for ELISA. Abnova's recommended working dilutions for western analysis are as follows: 1:500 dilution for ascites 1:1000 for purified Ig 1:500

Reactivity Notes

Human. Other species not tested.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Unpurified antisera so the specific antibody concentration is unknown. Contains 50% glycerol.
• Preservative: No Preservative
• Purity: Unpurified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for FYCO1 Antibody

• DKFZp779K1152
• FLJ13335
• FYVE and coiled-coil domain containing 1
• FYVE and coiled-coil domain-containing protein 1
• MGC126517
• RUFY3
• RUN and FYVE domain containing 3
• ZFYVE7MGC126519
• Zinc finger FYVE domain-containing protein 7

Background

FYCO1, Fyve and Coiled-Coil domain-containing 1, is a gene that is lost in chromosomal deletions in nearly all types of solid tumors. FYCO1 forms a complex with LC3 and Rab7 that promotes microtubule plus end-directed transport of autophagic vesicles. It is possible that FYCO1 has membrane-tethering functions as well.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for FYCO1 Antibody (H00079443-A01)(2)

Publications using H00079443-A01

• Hong Z, Pedersen NM, Wang L et al. PtdIns3P controls mTORC1 signaling through lysosomal positioning. J Cell Biol 2017-10-13 [PMID: 29030394]
• Pankiv S, Alemu EA, Brech A et al. FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport. J Cell Biol 2010-01-25 [PMID: 20100911]

Bioinformatics

• Gene Symbol: FYCO1
• Entrez:
  • 79443(Human)
• OMIM:
  • 607182(Human)
• Uniprot:
  • AAH07218(Human)