Frizzled-6 Antibody

Immunohistochemistry-Paraffin: Frizzled-6 Antibody [NLS4481] - Analysis of anti-Frizzled 6 / FZD6 antibody with human skeletal muscle at dilution 14 ug/ml.

Immunohistochemistry-Paraffin: Frizzled-6 Antibody [NLS4481] - Analysis of anti-Frizzled 6 / FZD6 antibody with human prostate.

Immunohistochemistry-Paraffin: Frizzled-6 Antibody [NLS4481] - Analysis of anti-Frizzled 6 / FZD6 antibody with human skeletal muscle.

Immunohistochemistry-Paraffin: Frizzled-6 Antibody [NLS4481] - Analysis of anti-Frizzled 6 / FZD6 antibody with human liver at dilution 14 ug/ml.

Immunohistochemistry-Paraffin: Frizzled-6 Antibody [NLS4481] - Analysis of anti-Frizzled 6 / FZD6 antibody with human pancreas.

Product Discontinued

Frizzled-6 Antibody Summary

• Immunogen: Synthetic 17 amino acid peptide from N-terminal extracellular domain of human Frizzled-6.
• Localization: Multi-pass membrane protein
• Specificity: Human Frizzled-6. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except MTMR10 (47%).
• Predicted Species: Equine (94%), Primate (94%), Monkey (94%), Bovine (94%), Orangutan (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: FZD6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 14 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (94%), Gibbon (94%), Marmoset (94%), Porcine (88%), Opossum (88%), Bat (82%), Rabbit (82%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Frizzled-6 Antibody

• frizzled (Drosophila) homolog 6
• frizzled homolog 6 (Drosophila)
• Frizzled6
• Frizzled-6
• FZ6
• fz-6
• FZD6
• Hfz6
• seven transmembrane helix receptor

Background

FZD6 is a Frizzled Receptor for Wnt signaling proteins involved in patterning during development. Contrary to other Frizzled proteins, FZD6 does not contain a C-terminal PDZ domain-binding motif. FZD6 is widely expressed. The Drosophila homolog activates Dishevelled. FZD6 expression has been reported in brain, colon, heart, kidney, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, testis, and thymus. Various tumor cell lines have also been shown to express FZD6. ESTs have been isolated from blood, brain, breast, connective tissue, liver, liver/spleen, lung, placenta, testis, thyroid, and vessel libraries. In addition, several ESTs have been isolated from tumor libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: FZD6
• Entrez:
  • 8323(Human)
• Uniprot:
  • O60353()