FNBP1 Antibody

Immunohistochemistry-Paraffin: FNBP1 Antibody [NBP2-27082] - analysis of FNBP1 in formalin-fixed, paraffin-embedded human brain tissue using an isotype control (top) and this antibody (bottom) at 5 ug/ml.

Product Discontinued

FNBP1 Antibody Summary

• Immunogen: A portion of amino acids 575-643 of human FNBP1 (isoform CRA_a) was used as the immunogen. 597 614
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: FNBP1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5ug/ml

Reactivity Notes

The amino acid sequence used as immunogen is 100% homologous in human (isoforms CRA_a, CRA_b, CRA_d), mouse, rat, chimp and horse.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 0.2 ml PBS and 0.05% BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Protein A purified

Alternate Names for FNBP1 Antibody

• FBP17KIAA0554Formin-binding protein 17
• formin binding protein 1
• formin-binding protein 1
• hFBP17
• MGC126804

Background

FNBP1 is a regulatory protein belonging to the formin-binding-protein family. It has a FCH domain, a coiled-coil domain, a Rho family protein-binding domain (RBD), and a SH3 domain. FNBP1 interacts with sorting nexin 2 (SNX2), tankyrase (TNkS), and dynamin and is an important regulator of endocytosis. It self associates and binds to lipids to promote membrane invagination and the formation of tubules. It acts as a link between RND2 signaling and regulation of the actin cytoskeleton. FNBP1 induces neurite branching in response to ARHN. The MLL-FNBP1 fusion protein with MLL has very low transforming ability. FNBP1 is associated with acute myelogemous leukemia. FNBP1 is very highly expressed in epithelial cells, brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon-producing cells of the pancreas, germ cells of the testis and brain.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: FNBP1
• Uniprot:
  • Q96RU3(Human)