FKBP13/FKBP2 Antibody (422617) [Alexa Fluor® 750]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: 422617
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 750

FKBP13/FKBP2 Antibody (422617) [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human FKBP13
  Ala22-Leu142
  Accession # P26885
• Specificity: Detects endogenous human, mouse, and rat FKBP13 at 13 kDa in Western blots. In Western blots, this antibody does not cross-react with recombinant human FKBP12, FKBP12.6, FKBP25, FKBP38, FKBP51, or FKBP52.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FKBP13/FKBP2 Antibody (422617) [Alexa Fluor® 750]

• EC 5.2.1.8,13 kDa FK506-binding protein
• FK506 binding protein 2, 13kDa
• FK506-binding protein 2 (13kD)
• FK506-binding protein 2
• FKBP13
• FKBP13,13 kDa FKBP
• FKBP-13proline isomerase
• FKBP2
• FKBP-2
• Immunophilin FKBP13
• peptidyl-prolyl cis-trans isomerase FKBP2
• PPIase FKBP2
• PPIase
• rapamycin-binding protein
• rotamase

Background

FK506 binding protein, 13 kDa molecular weight (FKBP13), also called FKBP2, is a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans-proline residues critical for proper folding of proteins. The macrolide immunosuppressant FK506 is a potent FKBP13 inhibitor. FKBP13 is strongly induced by calcium ionophores and agents that cause endoplasmic reticulum stress, such as tunicamycin. FKBP13 is membrane-associated and tightly bound to the cytoskeletal protein Band 4.1 in erythrocytes, suggesting a role in maintaining structural proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.