FKBP12.6 Antibody [Alexa Fluor® 647]

• Reactivity: Hu, Mu, Rt
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 647

FKBP12.6 Antibody [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human FKBP12.6
  Met1-Glu108
  Accession # P68106
• Specificity: Detects human, mouse, and rat FKBP12.6 in Western blots. In Western blots, approximately 15% cross-reactivity with recombinant human FKBP12 and less than 1% cross-reactivity with recombinant human FKBP13 and FKBP25 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FKBP12.6 Antibody [Alexa Fluor® 647]

• 12.6 kDa FK506-binding protein
• calstabin 2,12.6 kDa FKBP
• EC 5.2.1.8
• FK506 binding protein 1B, 12.6 kDa
• FK506-binding protein 12.6
• FK506-binding protein 1B (12.6 kD)
• FK506-binding protein 1B
• FKBP12.6
• FKBP-12.6
• FKBP12.6h-FKBP-12
• FKBP1B
• FKBP-1B
• FKBP1L
• FKBP9
• Immunophilin FKBP12.6
• OTK4
• OTK4PPIase FKBP1B
• peptidyl-prolyl cis-trans isomerase FKBP1B
• PKBP1L
• PPIase
• rotamase

Background

FK506 binding protein, 12.6 kDa molecular weight (FKBP12.6), also called FKBP1B, is a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans‑ proline residues critical for proper folding of proteins. The immunosuppressant FK506 is a potent inhibitor of FKBP12.6. FKBP12.6 is localized in the sarcoplasmic reticulum associated with the Ryanodyne receptor RYR2. PKA-induced phosphorylation of RYR2 causes FKBP12.6 dissociation. In heart failure, RYR2 is hyperphosphorylated and has low levels of FKBP12.6 bound to it. Male FKBP12.6 knockout mice have cardiac hypertrophy and lethal exercise arrhythmias.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.