FCRL3/FcRH3 Antibody (H5) [DyLight 650]

• Reactivity: Hu
• Applications: Flow
• Clone: H5
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 650

FCRL3/FcRH3 Antibody (H5) [DyLight 650] Summary

• Additional Information: Clone H5 was used by HLDA to establish CD designation.
• Immunogen: DNA-immunization followed by a boost with FCRL3/FcRH3 transfected cells
• Specificity: The mouse monoclonal antibody H5 recognizes an epitope within extracellular part of FCRL3/FcRH3, a transmembrane glycoprotein expressed mainly on NK cells, and T and B cell subsets.
• Isotype: IgG2b Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: FCRL3
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for FCRL3/FcRH3 Antibody (H5) [DyLight 650]

• CD307c
• Fc receptor homolog 3
• Fc receptor-like 3
• Fc receptor-like protein 3
• FcRH3
• FCRL3
• fcR-like protein 3
• hIFGP3
• IFGP3
• immunoglobulin superfamily receptor translocation associated protein 3
• IRTA3
• SPAP2

Background

The FCRL3 gene codes for a member of the immunoglobulin receptor superfamily, a Fc receptor-like protein 3 that has seven isoforms: isoform 1: 734 amino acids long, 80 kDA; isoform 2: 639 amino acids long, nearly 70 kDA; isoform 3: 740 amino acids long, 81 kDA; isoform 4: 189 amino acids long, 21 kDA; isoform 5: 199 amino acids long, 22 kDA; isoform 6: 742 amino acid long, 81 kDA; and isoform 7: 707 amino acids long, 77 kDA. This protein functions in the moderation of the immune system as it obtains immunoreceptor-tyrosine activation motifs as well as immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain. It is known to interact with genes SYK, PTPN6, ZAP70, and PTPN11. FCRL3 is linked to multiple sclerosis, graves' disease, arthritis, lupus, rheumatoid arthritis, alopecia areata, behcet's disease, and primary biliary cirrhosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: FCRL3