FBXW7/Cdc4 Antibody - BSA Free

Product Discontinued

FBXW7/Cdc4 Antibody - BSA Free Summary

• Immunogen: Synthetic peptide corresponding to the N terminus of isoform 2 of the FBXW7/Cdc4 protein.
• Specificity: Cdc4
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: FBXW7
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:100-1:2000
• Application Notes: The immunogen for this antibody corresponds to the N terminus of isoform 2 of the human FBXW7/Cdc4 protein (uniprot identifier: Q969H0-2)br> The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Theoretical MW: 100 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

This antibody is reactive against Human

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for FBXW7/Cdc4 Antibody - BSA Free

• AGO
• AGOFBXO30
• Archipelago Homolog
• archipelago, Drosophila, homolog of
• Cdc4
• CDC4FLJ16457
• F-box and WD repeat domain containing 7
• F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)
• F-box and WD-40 domain-containing protein 7
• F-box protein FBW7
• F-box protein FBX30
• F-box protein SEL-10
• F-box/WD repeat-containing protein 7
• FBW6
• Fbw7
• FBW7hCdc4
• FBX30
• FBX30FLJ11071
• FBXO30
• FBXW6
• FBXW7
• hAgo
• homolog of C elegans sel-10
• SCF(Fbw7)
• SEL10
• SEL-10DKFZp686F23254
• SEL10FBW6

Background

Fbw7/Cdc4 is a member of the F box protein family which are characterized by an approximately 40 amino acid motif, the F box. The F box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F box), which function in phosphorylation-dependent ubiquitination. The F box proteins are divided into 3 classes: Fbws containing WD40 domains, Fbls containing leucine rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. Fbw7 belongs to the Fbws class; in addition to an F box, this protein contains 7 tandem WD40 repeats. It binds directly to cyclin E and probably targets cyclin E for ubiquitin mediated degradation. Mutations of this gene are detected in ovarian and breast cancer cell lines. Alternative splicing of this gene generates 2 transcript variants diverging at the 5' termini.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: FBXW7
• Entrez:
  • 55294(Human)