ERManI Antibody (3C2) [DyLight 594]

• Reactivity: Hu, Mu(-)
• Applications: WB, ELISA, ICC/IF, IHC, IP, KO
• Clone: 3C2
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 594

ERManI Antibody (3C2) [DyLight 594] Summary

• Immunogen: Full length human recombinant ERManI [Swiss-Prot# Q9UKM7]
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: MAN1B1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Knockout Validated
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Does not react with mouse.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for ERManI Antibody (3C2) [DyLight 594]

• alpha 1,2-mannosidase
• EC 3.2.1.113
• endoplasmic reticulum alpha-mannosidase 1
• endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1
• endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
• ER alpha 1,2-mannosidase
• ER alpha-1,2-mannosidase
• ER ManI
• ER mannosidase 1
• ERMan1
• Man9GlcNAc2-specific processing alpha-mannosidase
• Man9GlcNAc2-specific-processing alpha-mannosidase
• MANA-ER
• Mannosidase alpha class 1B member 1
• mannosidase, alpha, class 1B, member 1
• MRT15
• RP11-350O14.2

Background

ERManI (MAN1B1) catalyzes the first mannose-trimming step in maturation of Asn-linked oligosaccharides. It trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2), specifically converting it to Man8GlcNAc isomer B. ERManI may be involved in glycoprotein quality control since it is important to target misfolded glycoproteins for degradation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MAN1B1