ENT1 Antibody

Product Discontinued

ENT1 Antibody Summary

• Immunogen: KLH-conjugated synthetic peptide between amino acids 234-263 from internal region of human ENT1.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SLC29A1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 10 ug/ml
  • Western Blot 1:1000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Purity: Protein A purified

Alternate Names for ENT1 Antibody

• ENT1
• ENT1es-type
• equilibrative nucleoside transporter 1
• MGC1465
• MGC3778
• SLC29A1
• solute carrier family 29 (nucleoside transporters), member 1
• Solute carrier family 29 member 1
• solute carrier family 29, member 1

Background

This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ENT1 Antibody (NBP1-50508)(3)

Publications using NBP1-50508

• Chen YH, Chen YC, Lin CC et al. Synergistic Anticancer Effects of Gemcitabine with Pitavastatin on Pancreatic Cancer Cell Line MIA PaCa-2 in vitro and in vivo Cancer Manag Res 2020-06-17 [PMID: 32606957]
• Russell J, Pillarsetty N, Kramer RM et al. In Vitro and In Vivo Comparison of Gemcitabine and the Gemcitabine Analog 1-(2'-deoxy-2'-fluoroarabinofuranosyl) Cytosine (FAC) in Human Orthotopic and Genetically Modified Mouse Pancreatic Cancer Models. Mol Imaging Biol. 2017-03-27 [PMID: 28349292]
• Hur Eun-Hye, Jung Seung-Hyun, Goo Bon-Kwan et al. Establishment and characterization of hypomethylating agent-resistant cell lines, MOLM/AZA-1 and MOLM/DEC-5. Oncotarget 2017-01-01 [PMID: 28052028] (WB, Human)

Bioinformatics

• Gene Symbol: SLC29A1
• Entrez:
  • 2030(Human)
• Uniprot:
  • Q99808(Human)