Dystrobrevin alpha Antibody (OTI1B2) [Janelia Fluor® 549]

• Reactivity: Hu, Mu, Rt
• Applications: Flow, ICC/IF
• Clone: OTI1B2
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 549

Dystrobrevin alpha Antibody (OTI1B2) [Janelia Fluor® 549] Summary

• Immunogen: Full length recombinant protein of human Dystrobrevin alpha (NP_116761) produced in HEK293T cells.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: DTNA
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Dystrobrevin alpha Antibody (OTI1B2) [Janelia Fluor® 549]

• Alpha-dystrobrevin
• D18S892EDTN
• DRP3FLJ96209
• DTN-1
• DTN-2
• DTN-3
• DTN-A
• dystrobrevin alpha
• dystrobrevin, alpha
• Dystrophin-related protein 3
• LVNC1

Background

Dystrobrevin alpha is encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DTNA