DYNC1H1 293T Cell Transient Overexpression Lysate

Product Discontinued

DYNC1H1 293T Cell Transient Overexpression Lysate Summary

• Description: Quality control test: Transient overexpression cell lysate was tested with Anti-DYNC1H1 antibody by Western Blots. Plasmid: pCMV-DYNC1H1 full-length
• Specificity: DYNC1H1 293T Cell Transient Overexpression Lysate(Denatured)
• Gene: DYNC1H1

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)

Lysate Details for Array

• Type: 293T Cell Transient Overexpression
• Protein State: Denatured

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for DYNC1H1 293T Cell Transient Overexpression Lysate

• cytoplasmic dynein 1 heavy chain 1
• Cytoplasmic dynein heavy chain 1
• DHC1a
• DHC1Dynein heavy chain, cytosolic
• DKFZp686P2245
• Dnchc1
• DNCLDNCH1
• DNECLDYHC
• dynein, cytoplasmic 1, heavy chain 1
• dynein, cytoplasmic, heavy polypeptide 1
• HL-3
• KIAA0325
• p22

Background

The DYNC1H1 gene encodes a cytoplasmic dynein 1 heavy chain 1 protein that is 4,646 amino acids long at 532 kDA. Dyneines function as molecular motors that contain ATPase activity. Defects in DYNC1H1 cause Charcot-Marie-Tooth Disease type 2O (CMT2O), mental retardation autosomal dominant type 13 (MRD13), as well as spinal muscular atrophy, lower extremity, autosomal dominant (SMALED). DYNC1H1 has also been investigated by researchers in myeloma, neuropathy, ciliary dyskinesia, lateral sclerosis, intellectual disabilities, lissencephaly, schizophrenia, malaria, and neurodegeneration. DYNC1H1 participates in centrosome maturation, adaptive immune system, cytoplasmic microtubules, cell cycle spindle assembly and chromosome separation, as well as phagosome and vasopressin-regulated water reabsorption. DYNC1H1 interacts with genes HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, and HIST1H43.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Lysates are guaranteed for 6 months from date of receipt.

Bioinformatics

• Gene Symbol: DYNC1H1