DRAP1 Antibody (PCRP-DRAP1-1A8) [Janelia Fluor® 669]

• Reactivity: Hu
• Applications: Flow, ICC/IF, IHC
• Clone: PCRP-DRAP1-1A8
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 669

DRAP1 Antibody (PCRP-DRAP1-1A8) [Janelia Fluor® 669] Summary

• Immunogen: Recombinant human DRAP1 protein
• Localization: Nucleus. Cytoplasm.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: DRAP1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry-Paraffin
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Predicted to react in Mouse, Rat and Chick.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for DRAP1 Antibody (PCRP-DRAP1-1A8) [Janelia Fluor® 669]

• dr1-associated corepressor
• DR1-associated protein 1 (negative cofactor 2 alpha)
• Dr1-associated protein 1
• NC2-alphaNegative co-factor 2-alpha
• negative cofactor 2 alpha

Background

Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DRAP1