DRAP1 Products

Description

Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq]

Bioinformatics

Entrez	10589 Human
Uniprot	NM_006442 Human NP_006433 Human NP_006433.2 Human
Product By Gene ID	10589
Alternate Names	Dr1-associated protein 1 negative cofactor 2 alpha dr1-associated corepressor NC2-alphaNegative co-factor 2-alpha DR1-associated protein 1 (negative cofactor 2 alpha)

Diseases related to DRAP1

Discover more about diseases related to DRAP1.

Radiation Injury
Malignant Neoplasm Of Prostate
Burkitt Lymphoma
Teratoma
Liver Carcinoma
Muscular Fasciculation
Hypoxia
Acute Basophilic Leukemia
Punctate Inner Choroidopathy
Gastrointestinal Hemorrhage
Rectal Diseases
Polycystic Kidney Diseases
Tumor Angiogenesis
Malignant Neoplasms
Prostatic Neoplasms
Hemorrhage
Nervousness
Kidney Diseases
Rectal Hemorrhage

Pathways for DRAP1

View related products by pathway and learn more about each of the pathways below.

Gastrulation
Localization
Cell Cycle
Cell Growth
Transport
Cell Development
Photosynthesis
Response To Hypoxia
Dna Repair
Nuclear Export
Epithelial To Mesenchymal Transition
Cell Motility
Angiogenesis
Nuclear Import
Chromatin Remodeling

PTMs for DRAP1

Learn more about PTMs related to DRAP1.

Phosphorylation

Bioinformatics Tool for DRAP1

Discover related pathways, diseases and genes to DRAP1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.