DRAK2 Antibody (685228) [Alexa Fluor® 750]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: 685228
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

DRAK2 Antibody (685228) [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human DRAK2
  Ala87-Glu285 (predicted)
  Accession # O94768
• Specificity: Detects human, mouse, and rat DRAK2 in Western blots. In Western blots, less than 10% cross-reactivity with recombinant human (rh) DRAK1, rhDAPK1, rhDAPK2, or rhDAPK3 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for DRAK2 Antibody (685228) [Alexa Fluor® 750]

• DAP kinase-related apoptosis-inducing protein kinase 2
• DRAK2
• DRAK2death-associated protein kinase-related 2
• EC 2.7.11
• EC 2.7.11.1
• serine/threonine kinase 17b (apoptosis-inducing)
• serine/threonine kinase 17b
• serine/threonine-protein kinase 17B
• STK17B

Background

DRAK2 (death-associated protein related kinase-2), also called STK17B (Ser/Thr kinase 17B) is a 45 kDa member of the DAPK (death-associated protein kinase) family. It is expressed mainly in lymphoid organs by mature T cells and B cells. It is autophosphorylated on Ser12 after TCR stimulation and negatively regulates TCR signaling. Ultraviolet light causes phosphorylation on Ser350 and translocation to the nucleus to stimulate apoptosis. Within the region used as an immunogen, human DRAK2 shares 95% amino acid (aa) identity with mouse and rat DRAK2 while mouse and rat DRAK2 share 99.5% aa identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.