DOG1/TMEM16A Antibody (DG1/447 + DOG-1.1) [DyLight 405]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, ICC/IF, IHC-Fr, IHC-P
Clone
DG1/447 + DOG-1.1
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 405

DOG1/TMEM16A Antibody (DG1/447 + DOG-1.1) [DyLight 405] Summary

Immunogen
Recombinant human DOG-1 protein (DG1/447); A synthetic peptide from human DOG-1 protein (MSDFVDWVIPDIPKDISQQIHK-EKVLMVELFMREEQDKQQLLETCMEKER QKDEPPCNHHNTKACPDSLGSPAPSHAYHGGVL), conjugated to a carrier protein (DOG-1.1)
Localization
Cell Surface and Cytoplasmic
Marker
Gastrointestinal Stromal Tumor Marker
Specificity
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.
Isotype
IgG
Clonality
Monoclonal
Host
Mouse
Gene
ANO1
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Theoretical MW
114 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for DOG1/TMEM16A Antibody (DG1/447 + DOG-1.1) [DyLight 405]

  • ANO1
  • anoctamin 1
  • DOG1
  • ORAOV2
  • TAOS2
  • TMEM16A

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for DOG1/TMEM16A Antibody (NBP2-34604V) (0)

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Secondary Antibodies

 

Isotype Controls

Additional DOG1/TMEM16A Products

Bioinformatics Tool for DOG1/TMEM16A Antibody (NBP2-34604V)

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Diseases for DOG1/TMEM16A Antibody (NBP2-34604V)

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Bioinformatics

Gene Symbol ANO1