Dishevelled-2 Antibody (373413) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: WB
• Clone: 373413
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

Dishevelled-2 Antibody (373413) [Alexa Fluor® 488] Summary

• Immunogen: E. coli-derived recombinant human Dishevelled-2
  Leu78-Thr250
  Accession # O14641
• Specificity: Detects human Dishevelled‑2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) DVL-1 or rhDVL-3 is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Dishevelled-2 Antibody (373413) [Alexa Fluor® 488]

• dishevelled 2 (homologous to Drosophila dsh)
• dishevelled, dsh homolog 2 (Drosophila)
• Dishevelled2
• Dishevelled-2
• DSH homolog 2
• DVL2
• segment polarity protein dishevelled homolog DVL-2

Background

Dishevelled-2 (DVL-2) is a 90‑95 kDa cytoplasmic phosphoprotein that is one of the three Drosophila dishevelled orthologs. Human DVL-2 is expressed in multiple tissues, participates in Wnt signal transduction and may mediate Wnt-dependent motility. DVL-2 is a modular protein containing DIX, PDZ and DEP linker regions that connect Wnt/Frizzled engagement to proteins involved in the inactivation of beta -catenin destruction in the Wnt canonical pathway. Human and mouse DVL-2 share 94% aa identity over the sequence used for immunization.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.