Desmoglein-3 Antibody (5G11) [Janelia Fluor® 585]

Product Discontinued

Desmoglein-3 Antibody (5G11) [Janelia Fluor® 585] Summary

• Immunogen: Human Desmoglein 3 recombinant protein [UniProt# P32926]
• Specificity: This antibody reacts with Desmoglein-3. Does not cross-react with Desmoglein 1 or Desmoglein 2.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: DSG3
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Dot Blot
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Desmoglein-3 Antibody (5G11) [Janelia Fluor® 585]

• Cadherin family member 6
• CDHF6
• CDHF6130-kD pemphigus vulgaris antigen
• desmoglein 3 (pemphigus vulgaris antigen)
• desmoglein 3
• Desmoglein3
• Desmoglein-3
• DKFZp686P23184,130 kDa pemphigus vulgaris antigen
• DSG3
• pemphigus vulgaris antigen
• PVA

Background

Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DSG3