DCK Antibody

Western Blot: DCK Antibody [H00001633-B01P] - Analysis of DCK expression in transfected 293T cell line by DCK polyclonal antibody. Lane 1: DCK transfected lysate(28.6 KDa). Lane 2: Non-transfected lysate.

Immunocytochemistry/Immunofluorescence: DCK Antibody [H00001633-B01P] - Analysis of purified antibody to DCK on HeLa cell. (antibody concentration 10 ug/ml)

Product Discontinued

DCK Antibody Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: DCK (NP_000779, 1 a.a. - 260 a.a.) full-length human protein. MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL
• Specificity: Reacts with deoxycytidine kinase.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: DCK
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: This antibody is reactive against transfected lysate in WB, IF and as a detection antibody in ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for DCK Antibody

• DCK
• deoxycytidine kinase
• EC 2.7.1
• EC 2.7.1.113
• EC 2.7.1.74
• EC 2.7.1.76
• MGC117410
• MGC138632

Background

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for DCK Antibody (H00001633-B01P)(1)

Publication using H00001633-B01P

• Agrawal K, Das V, Taborska N et al. Differential Regulation of Methylation-Regulating Enzymes by Senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs Stem Cells Int 2018-08-12 [PMID: 30158986] (WB, Human)

Bioinformatics

• Gene Symbol: DCK
• Entrez:
  • 1633(Human)
• Uniprot:
  • NP_000779(Human)