DCK Antibody (1D12)

Product Discontinued

DCK Antibody (1D12) Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: DCK (NP_000779 161 a.a. - 260 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. WMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL
• Specificity: deoxycytidine kinase
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: DCK
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for DCK Antibody (1D12)

• DCK
• deoxycytidine kinase
• EC 2.7.1
• EC 2.7.1.113
• EC 2.7.1.74
• EC 2.7.1.76
• MGC117410
• MGC138632

Background

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for DCK Antibody (H00001633-M08)(1)

Publication using H00001633-M08

• Costantino CL, Witkiewicz AK, Kuwano Y et al. The Role of HuR in Gemcitabine Efficacy in Pancreatic Cancer: HuR Up-regulates the Expression of the Gemcitabine Metabolizing Enzyme Deoxycytidine Kinase. Cancer Res. 2009-06-01 [PMID: 19487279]

Bioinformatics

• Gene Symbol: DCK
• Entrez:
  • 1633(Human)
• OMIM:
  • 125450(Human)
• Uniprot:
  • NP_000779(Human)