Cysteine Conjugate beta-Lyase/CCBL1 Antibody

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Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line, HepG2 human hepatocellular carcinoma cell line, mouse kidney tissue, and rat kidney tissue. PVDF membrane was probed with 0.5 µg/mL of ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

Cysteine Conjugate beta-Lyase/CCBL1 Antibody Summary

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Cysteine Conjugate beta -Lyase/CCBL1
Thr182-Leu422
Accession # Q16773
Specificity
Detects human, mouse, and rat Cysteine Conjugate beta -Lyase/CCBL1 in Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
CCBL1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.5 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Sterile PBS to a final concentration of 0.2 mg/mL.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Cysteine Conjugate beta-Lyase/CCBL1 Antibody

  • CCBL1
  • Cysteine Conjugate betaLyase
  • Cysteine Conjugate beta-Lyase
  • cysteine conjugate-beta lyase, cytoplasmic
  • cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K
  • Cysteine-S-conjugate beta-lyase
  • EC 2.6.1.64
  • EC 2.6.1.7
  • EC 4.4.1.13
  • FLJ95217
  • Glutamine Transaminase K
  • glutamine-phenylpyruvate aminotransferase
  • Glutamine--phenylpyruvate transaminase
  • GTKMGC29624
  • KAT1
  • KATI
  • KATIbeta-lysase, kidney
  • Kyneurenine Aminotransferase I
  • kyneurenine aminotransferase
  • kyneurenine aminotransferase)
  • Kynurenine aminotransferase I
  • kynurenine--oxoglutarate transaminase 1
  • Kynurenine--oxoglutarate transaminase I

Background

CCBL1 (Cysteine Conjugate beta -Lyase 1; also GTK and KAT-I) is a 90-120 kDa homodimeric member of the Class I Pyridoxyl-phosphate-dependent aminotransferase family of enzymes. It is widely expressed, being found in fibroblasts, renal epithelium, hepatocytes, neurons and astrocytes. CCBL1 has multiple activities, including converting prodrugs into active formulations, generating kynurenic acid from kynurenine, thereby antagonizing NMDA receptors (but not likely presynaptic alpha 7 AChRs), and blocking the release of proinflammatory cytokines by microglia via GPCR-35 antagonism. Human CCBL1 is 422 amino acids (aa) in length, and contains one aspartate aminotransferase-like region (aa 31-417). There are three potential splice variants, one that shows a deletion of aa 68-117, a second that shows a deletion of aa 251-422, and a third that contains a 21 aa substitution for aa 230-250. While the 422 aa isoform is considered cytosolic, there is the potential for a 34 aa N-terminal extension that would act as a mitochondrial targeting sequence. Such a sequence is reported for rat and nonhuman primate. Over aa 182-422, human CCBL1 shares 82% aa sequence identity with mouse CCBL1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CCBL1
Entrez
Uniprot