Recombinant Human Cyr61/CCN1 Protein

Product Discontinued

Recombinant Human Cyr61/CCN1 Protein Summary

• Protein/Peptide Type: Recombinant Protein
• Gene: CCN1

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunoaffinity Purification
  • Protein Array
  • Western Blot
• Application Notes: Useful in Western Blot and ELISA. This protein has not been tested for any functionality. This product may contain endotoxins and is not suitable for use with live cells.

Reactivity Notes

Human

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Recombinant Human Cyr61/CCN1 Protein

• CCN family member 1
• CCN1
• CCN1IGF-binding protein 10
• Cyr61
• Cysteine-rich angiogenic inducer 61
• cysteine-rich, angiogenic inducer, 61
• GIG1
• GIG1cysteine-rich heparin-binding protein 61
• IBP-10
• IGFBP-10
• IGFBP10cysteine-rich, anigogenic inducer, 61
• Insulin-like growth factor-binding protein 10
• protein CYR61
• Protein GIG1

Background

CYR61( AAH01271, 1 a.a. - 382 a.a.) recombinant protein with GST.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 1 year from date of receipt.

Publications for Cyr61/CCN1 Recombinant Protein (H00003491-P01)(17)

Publications using H00003491-P01

• Zhao G, Huang BL, Rigueur D et al. CYR61/CCN1 Regulates Sclerostin Levels and Bone Maintenance. J Bone Miner Res 2018-01-19 [PMID: 29351359]
• Jeansonne D, Pacifici M, Lassak A et al. Differential Effects of MicroRNAs on Glioblastoma Growth and Migration. Genes (Basel) 2014-04-08 [PMID: 24705102]
• You JJ, Yang CH, Yang CM et al. Cyr61 induces the expression of monocyte chemoattractant protein-1 via the integrin ???3, FAK, PI3K/Akt, and NF-?B pathways in retinal vascular endothelial cells. Cell Signal 2013-09-22 [PMID: 24063814]
• Kok SH, Lin LD, Hou KL et al. Simvastatin inhibits Cyr61 expression in rheumatoid arthritis synovial fibroblasts through the regulation of SIRT1/FoxO3a signaling. Arthritis Rheum 2012-12-12 [PMID: 23239110]
• Wu PH, Lin SK, Lee BS et al. Epigallocatechin-3-gallate diminishes cytokine-stimulated Cyr61 expression in human osteoblastic cells: a therapeutic potential for arthritis. Rheumatology (Oxford) 2012-06-11 [PMID: 22843790]
• Terada N, Shiraishi T, Zeng Y et al. Cyr61 is regulated by cAMP-dependent protein kinase with serum levels correlating with prostate cancer aggressiveness. Prostate 2011-10-24 [PMID: 22025384]
• You JJ, Yang CM, Chen MS et al. Regulation of Cyr61/CCN1 expression by hypoxia through cooperation of c-Jun/AP-1 and HIF-1? in retinal vascular endothelial cells. Exp Eye Res 2010-10-26 [PMID: 21029732]
• Su JL, Chiou J, Tang CH et al. CYR61 regulates BMP-2-dependent osteoblast differentiation through {alpha}v{beta}3 integrin/ILK/ERK pathway. J Biol Chem 2010-07-30 [PMID: 20675382]
• Chai J, Norng M, Modak C et al. CCN1 induces a reversible epithelial-mesenchymal transition in gastric epithelial cells. Lab Invest 2010-05-10 [PMID: 20458273]
• Kok SH, Hou KL, Hong CY et al. Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: A therapeutic benefit for arthritis. Arthritis Rheum 2010-02-26 [PMID: 20191585]
• Bar A, Dorfman SE, Fischer P et al. The pro-angiogenic factor CCN1 enhances the re-endothelialization of biological vascularized matrices in vitro. Cardiovasc Res 2009-12-16 [PMID: 19920130]
• You JJ, Yang CH, Chen MS et al. Cysteine-rich 61, a Member of the CCN Family, as a Factor Involved in the Pathogenesis of Proliferative Diabetic Retinopathy. Invest Ophthalmol Vis Sci 2009-03-05 [PMID: 19264885]
• Lin MT, Kuo IH, Chen CC et al. Involvement of HIF-1alpha -dependent PAI-1 up-regulation in Cyr61/CCN1 induced gastric cancer cell invasion. J Biol Chem 2008-04-01 [PMID: 18381294]
• Lin BR, Chang CC, Chen LR et al. Cysteine-Rich 61 (CCN1) Enhances Chemotactic Migration, Transendothelial Cell Migration, and Intravasation by Concomitantly Up-Regulating Chemokine Receptor 1 and 2. Mol Cancer Res 2007-11-01 [PMID: 18025257]
• Athanasopoulos AN, Schneider D, Keiper T et al. VEGF-induced upregulation of CCN1 in osteoblasts mediates proangiogenic activities in endothelial cells and promotes fracture healing. J Biol Chem 2007-07-10 [PMID: 17626014]
• Grote K, Salguero G, Ballmaier M et al. The angiogenic factor CCN1 promotes adhesion and migration of circulating CD34+ progenitor cells: potential role in angiogenesis and endothelial regeneration. Blood 2007-04-11 [PMID: 17429007]
• O'Connor RS, Mills ST, Jones KA et al. A combinatorial role for NFAT5 in both myoblast migration and differentiation during skeletal muscle myogenesis. J Cell Sci 2006-12-01 [PMID: 17164296]

Bioinformatics

• Gene Symbol: CCN1