CROCC Antibody (2734A) [Alexa Fluor® 594]

• Reactivity: Hu
• Applications: WB, ICC/IF
• Clone: 2734A
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Alexa Fluor 594

CROCC Antibody (2734A) [Alexa Fluor® 594] Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: Phosphopeptide containing the human CROCC S site 1476
  Accession # Q5TZA2
• Specificity: Detects Human Phospho-CROCC in direct ELISA
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CROCC Antibody (2734A) [Alexa Fluor® 594]

• CROCC ciliary rootlet coiled-coil, rootletin
• CROCC
• CROCC1
• KIAA0445
• ROLT
• TAX1BP2

Background

Human CROCC (also known as Rootletin) is a large coiled-coil protein that is primarily expressed in ciliated cells and plays a critical role in the organization and maintenance of the ciliary structure. Cilia are hair-like structures that protrude from the surface of many eukaryotic cells and are involved in a variety of cellular functions, including motility and signaling.CROCC is essential for forming and maintaining the rootlet and has been shown to interact with other centrosomal and ciliary proteins, such as PCM-1, C-Nap1, and CEP68. CROCC has also been shown to interact with microtubules, suggesting that it may play a role in regulating microtubule dynamics. CROCC can be Phosphorylated by NEK2 which may regulate its association with centrosomes. This antibody detects CROCC phosphorylated at Ser1476. Two alternatively spliced isoforms have been reported.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.