CRMP2 Antibody (33CT11.40.3)

Images

 
Western Blot: CRMP2 Antibody (33CT11.40.3) [NBP1-50580] - Mouse NIH/3T3 cell line, diluted at 1:2000. Goat anti-mouse at 1:3000 dilution was used as the secondary antibody. Lysate at 20ug.
Immunohistochemistry-Paraffin: CRMP2 Antibody (33CT11.40.3) [NBP1-50580] - Analysis of anti-CRMP-2 antibody with human kidney at dilution 1:200.
Immunohistochemistry-Paraffin: CRMP2 Antibody (33CT11.40.3) [NBP1-50580] - Analysis of anti-CRMP-2 antibody with human testis at dilution 1:200.

Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, ChSpecies Glossary
Applications WB, IHC-P
Clone
33CT11.40.3
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

CRMP2 Antibody (33CT11.40.3) Summary

Immunogen
KLH-conjugated synthetic peptide between amino acids 463-492 from human DRP-2.
Predicted Species
Rat (90%), Chicken (90%), Bovine (90%). Backed by our 100% Guarantee.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
DPYSL2
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:2000
  • Immunohistochemistry-Paraffin 1:200

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Ascites
Preservative
0.9% Sodium Azide
Purity
Unpurified

Alternate Names for CRMP2 Antibody (33CT11.40.3)

  • Collapsin response mediator protein 2
  • CRMP-2
  • CRMP2N2A3
  • DHPRP2
  • dihydropyrimidinase-like 2 long form
  • dihydropyrimidinase-like 2
  • dihydropyrimidinase-related protein 2
  • DRP2collapsin response mediator protein hCRMP-2
  • DRP-2ULIP-2
  • ULIP2
  • Unc-33-like phosphoprotein 2

Background

Collapsin response mediator proteins (CRMPs) are cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance. CRMP2 was previously shown to mediate the repulsive effect of Sema3A on axons and to participate in axonal specification. The CRMPs appear to play a complex role in axon growth as well as microtubule dynamics and axon induction. CRMPs localize to the lamellipodia and filopodia of axonal growth cones, suggesting a role in axon guidance. Moreover, CRMP2 is upregulated after axotomy, and appears to increase the formation of axon-type processes from hippocampal neurons. CRMP2 has been reported to bind tubulin dimers directly and modulate microtubule assembly. CRMPs have also been implicated in the pathogenesis of a paraneoplastic neurologic syndrome. Interaction studies have implicated phospholipase D2 (PLD2), the cytosolic tyrosine kinase Fes, and intersectin in CRMP function. Hyperphosphorylation of CRMP2 is an early event in the progression of Alzheimer's disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol DPYSL2
Entrez
Uniprot