CRLR Antibody - BSA Free

Immunohistochemistry-Paraffin: CRLR Antibody [NLS6755] - lung, alveoli

Immunohistochemistry-Paraffin: CALCRL Antibody [NLS6755] - Analysis of anti-CALCRL / CGRP Receptor antibody with colon, submucosal vessels at 16 ug/ ml.

Immunohistochemistry-Paraffin: CALCRL Antibody [NLS6755] - Analysis of anti-CALCRL / CGRP Receptor antibody with human bone, osteosarcoma.

Immunohistochemistry-Paraffin: CALCRL Antibody [NLS6755] - Human Lung, Non-Small Cell Carcinoma formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: CALCRL Antibody [NLS6755] - Human Ovary, Carcinoma formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: CRLR Antibody [NLS6755] - prostate, adenocarcinoma

Immunohistochemistry-Paraffin: CRLR Antibody [NLS6755] - Brain Hypothalamus Neurons

• Reactivity: Hu, Mu, Pm-Or, Pm
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

CRLR Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 15 amino acid peptide from N-terminal extracellular domain of human CRLR.
• Epitope: N-Terminus extracellular domain
• Specificity: Human CALCRL. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Mouse (93%), Orangutan (100%), Primate (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CALCRL
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 16 ug/ml
• Application Notes: .

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (93%), Rat (87%), Canine (87%), Equine (87%), Porcine (87%), Goat (80%), Bovine (80%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for CRLR Antibody - BSA Free

• calcitonin gene-related peptide type 1 receptor
• calcitonin receptor-like
• CALCRL
• CGRP type 1 receptor
• CGRPR
• CGRPRCRLRCalcitonin receptor-like receptor
• CRLR

Background

Calcitonin receptor-like receptor (CRLR) is an Adrenomedullin Receptor that requires two additional proteins to function: a chaperone protein RAMP (receptor activity modifying protein) and the component protein RCP. The function of CRLR depends on its interaction with RAMP. When coexpressed with RAMP1, CRLR acts as a receptor for calcitonin gene-related peptide (CGRP). In contrast, when CRLR is coexpressed with either RAMP2 or RAMP3, it acts as a receptor for adrenomedullin. Activation of the receptor leads to an increase in intracellular cyclic AMP. CRLR mediates the vasorelaxation of arteries, suggesting a potential role for the receptor in reaction to injury, particularly in the treatment of pulmonary hypertension. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B-Cell/lung/testis, bone marrow, embryo, lung, and synovium libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CRLR Antibody (NLS6755)(1)

Publication using NLS6755

• Gong Y, Wei JP, Wang TH et al. Calcitonin gene-related peptide receptor Calcrl is enriched in hair follicles stem cells and differentially expressed in interfollicular epidermis in murine skin Neuroreport 2020-08-05 [PMID: 32576770] (IF/IHC)

Bioinformatics

• Gene Symbol: CALCRL
• Entrez:
  • 10203(Human)