CRLR Products

Description

Calcitonin receptor-like receptor (CRLR) is an Adrenomedullin Receptor that requires two additional proteins to function: a chaperone protein RAMP (receptor activity modifying protein) and the component protein RCP. The function of CRLR depends on its interaction with RAMP. When coexpressed with RAMP1, CRLR acts as a receptor for calcitonin gene-related peptide (CGRP). In contrast, when CRLR is coexpressed with either RAMP2 or RAMP3, it acts as a receptor for adrenomedullin. Activation of the receptor leads to an increase in intracellular cyclic AMP. CRLR mediates the vasorelaxation of arteries, suggesting a potential role for the receptor in reaction to injury, particularly in the treatment of pulmonary hypertension. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B-Cell/lung/testis, bone marrow, embryo, lung, and synovium libraries.

Bioinformatics

Entrez	10203 Human
Uniprot	NP_005786.1 Human
Product By Gene ID	10203
Alternate Names	calcitonin gene-related peptide type 1 receptor calcitonin receptor-like CALCRL CGRP type 1 receptor CGRPR CGRPRCRLRCalcitonin receptor-like receptor CRLR

Research Areas for CRLR

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GPCR