CRHR2/CRF2 Antibody

Product Discontinued

CRHR2/CRF2 Antibody Summary

• Immunogen: Synthetic 18 amino acid peptide from 1st extracellular domain of human CRHR2.
• Localization: Multi-pass membrane protein.
• Specificity: Human CRHR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Porcine (94%), Bovine (94%), Rabbit (94%), Hamster (94%), Canine (94%), Primate (94%), Monkey (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CRHR2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 13 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (94%), Marmoset (94%), Mouse (89%), Rat (89%), Bat (89%), Equine (89%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for CRHR2/CRF2 Antibody

• corticotropin releasing hormone receptor 2
• corticotropin-releasing factor receptor 2
• Corticotropin-releasing hormone receptor 2
• CRF2
• CRF2R
• CRFR2
• CRF-R2
• CRF-R-2
• CRFR-2
• CRF-RB
• CRH2R
• CRHR2
• CRH-R2
• CRH-R-2
• HM-CRF

Background

CRHR2, a Corticotropin-Releasing Factor Receptor is a neuroregulator of the hypothalamic-pituitary-adrenocortical axis and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Mutations of the receptor reduce coping behaviors to stress and increase basal blood pressure. Three isoforms of CRHR2 are produced by alternative splicing. CRHR2 expression has been reported in various regions of the brain, as well as in placenta, umbilical vein, heart, epididymis, gastrointestinal tract, adrenal, and skeletal muscle. CRCH2alpha is the dominant isoform and is expressed widely. CRCH2beta is expressed in the hippocampus, septum, amygdala, heart, and skeletal muscle. CRHR2gamma is brain-specific. ESTs have been isolated from brain libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CRHR2
• Entrez:
  • 1395(Human)
• Uniprot:
  • Q13324(Human)