Complement Component C3aR Antibody (hC3aRZ1) - BSA Free

• Reactivity: Hu
• Applications: Flow, IHC
• Clone: hC3aRZ1
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

Complement Component C3aR Antibody (hC3aRZ1) - BSA Free Summary

• Immunogen: Recombinant human C3aR protein
• Specificity: NB100-64835 recognizes the receptor for human complement component C3a (C3aR), a 55kD cell surface protein of the rhodopsin family of G protein-coupled seven-transmembrane receptors. C3a is an anaphylatoxin, which is a potent proinflammatory mediator that possesses immunoregulatory properties. C3a regulates inflammatory functions by binding to the C3a receptor. C3aR is expressed on various tissues and leucocytes including basophils, neutrophils, mast cells, eosinophils and activated T lymphocytes.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: C3AR1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:10-1:20
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for Complement Component C3aR Antibody (hC3aRZ1) - BSA Free

• AZ3B
• AZ3BC3a anaphylatoxin chemotactic receptor
• C3AR
• C3a-R
• C3AR1
• C3ARcomplement component 3 receptor 1
• C3R1
• complement component 3a receptor 1
• Complement Component C3a R
• Complement Component C3aR
• HNFAG09

Background

The complement factor C3 consists of an alpha and a beta chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical mannose binding lectin activation pathway leads to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to the formation of the alpha chain products C3d, C3g and C3c. C3 is an acute phase protein that is produced by a wide range of tissues, including renal epithelial cells and hepatocytes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: C3AR1
• Entrez:
  • 719(Human)
• Uniprot:
  • Q16581()
  • Q16581()