CIDEB Antibody

Product Discontinued

CIDEB Antibody Summary

• Immunogen: Rabbit anti CIDEB (CT) polyclonal antibody was raised against a peptide corresponding to amino acids 204 to 219 of murine CIDEB (1).
• Specificity: CIDE-B. It has no cross-reactivity to CIDE-A.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CIDEB
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500-1:1000
• Application Notes: Tissue lysate of murine liver can be used as positive control.
• Theoretical MW: 25 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Mouse

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Purity: IgG purified

Alternate Names for CIDEB Antibody

• cell death-inducing DFFA-like effector bcell death activator CIDE-B

Background

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE-A and CIDEB (for cell death-inducing DFF-like effector A and B) were recently identified (1). CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD (1,2). Expression of CIDEB induces apoptosis, which is inhibited by DFF45. CIDEB is a DFF45-inhibitable effector that promotes cell death and DNA fragmentation. CIDEB is expressed mainly in liver and at lower levels in spleen, kidney, peripheral blood lymphocytes, and bone marrow (1).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CIDEB
• Entrez:
  • 12684(Mouse)
• Uniprot:
  • O70303(Mouse)