CIB1 Antibody (1D1) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Applications: WB, ELISA, ICC/IF
• Clone: 1D1
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

CIB1 Antibody (1D1) [Alexa Fluor™ Plus 647] Summary

• Immunogen: Recombinant human CIB1 (1-191aa) purified from E. coli
• Isotype: IgG2b Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: CIB1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for CIB1 Antibody (1D1) [Alexa Fluor™ Plus 647]

• calcium and integrin binding 1 (calmyrin)
• Calcium- and integrin-binding protein
• Calmyrin
• CIB1
• CIBcalcium and integrin binding protein
• CIBP
• DNA-dependent protein kinase interacting protein
• DNA-PKcs-interacting protein
• Kinase-interacting protein
• KIP
• KIP1
• KIPcalcium and integrin binding, protein kinase interacting protein
• PRKDCIP
• SIP2-28
• SIP2-28calcium and integrin-binding protein 1
• Snk interacting protein 2-28
• SNK-interacting protein 2-28

Background

CIB1(also designated calcium and integrin binding 1 or calmyrin),with 191-amino acid protein(about 21kDa), belongs to the calcium-binding protein family.CIB1 is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining.CIB1 is an EF-hand-containing protein that binds multiple effector proteins, including the platelet alpha(IIb)beta(3) integrin and several serine/threonine kinases and potentially modulates their function.CIB1 regulates platelet aggregation in hemostasis through a specific interaction with the alpha(IIb) cytoplasmic domain of platelet integrin alpha(IIb)beta(3). CIB1 is also ubiquitously expressed activating and inhibiting protein ligand of the InsP3R.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CIB1