Centrin 3 Antibody (3E6) Summary
CETN3 (AAH05383, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag.MSLALRSELVVDKTKRKKRRELSEEQKQEIKDAFELFDTDKDEAIDYHELKVAMRALGFDVKKADVLKILKDYDREATGKITFEDFNEVVTDWILERDPH
CETN3 - centrin, EF-hand protein, 3 (CDC31 homolog, yeast)
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
PBS (pH 7.4)
Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.
Western Blot 1:500 ELISA 1:100-1:2000 Immunocytochemistry/Immunofluorescence 1:10-1:2000 Sandwich ELISA 1:100-1:2000
Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for RNAi validation and ELISA. Use in ICC/IF reported in scientific literature (PMID: 23644468).
Publications using H00001070-M01 in the following applications:
Zebrafish reactivity reported in scientific literature (PMID: 25344692).
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for Centrin 3 Antibody (3E6)
CDC31 yeast homolog CEN3centrin, EF-hand protein, 3 (CDC31 homolog, yeast) centrin, EF-hand protein, 3 (CDC31 yeast homolog) centrin, EF-hand protein, 3 centrin-3 EF-hand superfamily member MGC12502 MGC138245 Background
The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
for 1 year from date of receipt.
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Publications for Centrin 3 Antibody (H00001070-M01)(19)
We have publications tested in 2 confirmed species: Human, Zebrafish.
We have publications tested in 3 applications: ICC/IF, IP, WB.
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Publications using H00001070-M01
Sawant DB, Majumder S, Perkins JL et al. Centrin 3 is an inhibitor of centrosomal Mps1 and antagonizes Centrin 2 function. Mol. Biol. Cell 2015 Sep 09 [PMID:26354417] (WB, IP, Human) WB, IP
Antonczak AK, Mullee LI, Wang Y et al. Opposing effects of pericentrin and microcephalin on the pericentriolar material regulate CHK1 activation in the DNA damage response. Oncogene. 2015 Jul 13 [PMID:26165835]
Martin Ca, Ahmad I, Klingseisen A et al. Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. Nat. Genet. 2014 Oct 26 [PMID:25344692] (ICC/IF, Zebrafish) ICC/IF
Kaczmarczyk A, Sullivan KF. CENP-W Plays a Role in Maintaining Bipolar Spindle Structure. PLoS One. 2014 Oct 15 [PMID:25329824]
Lee Yin Loon, Sante Joshua, Comerci Colin J et al. Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function. Mol Biol Cell. 2014 Oct 01 [PMID:25103236] (WB) WB
Maki-Jouppila Jenni H E, Laine Leena J, Rehnberg Jonathan et al. Centmitor-1, a novel acridinyl-acetohydrazide, possesses similar molecular interaction field and antimitotic cellular phenotype as rigosertib, on 01910.Na. Mol Cancer Ther. 2014 Apr 18 [PMID:24748653] (Human)
Sir JH, Putz M, Daly O et al. Loss of centrioles causes chromosomal instability in vertebrate somatic cells. J Cell Biol. 2013 Dec 02 [PMID:24297747]
Inanc B, Puetz M, Lalor P et al. Abnormal centrosomal structure and duplication in Cep135-deficient vertebrate cells. Mol Biol Cell. 2013 Jul 17 [PMID:23864714]
Dantas TJ, Daly OM, Conroy PC et al. Calcium-Binding Capacity of Centrin2 Is Required for Linear POC5 Assembly but Not for Nucleotide Excision Repair. PLoS One. 2013 Jul 02 [PMID:23844208]
Patel K, Scrimieri F, Ghosh S et al. FAM190A Deficiency Creates a Cell Division Defect. Am J Pathol. 2013 May 09 [PMID:23665203]
Show All 19 Publications.
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