Centrin 3 Antibody (3E6.) Summary
CETN3 (AAH05383, 1 a.a. - 100 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MSLALRSELVVDKTKRKKRRELSEEQKQEIKDAFELFDTDKDEAIDYHELKVAMRALGFDVKKADVLKILKDYDREATGKITFEDFNEVVTDWILERDPH
CETN3 - centrin, EF-hand protein, 3 (CDC31 homolog, yeast)
Test in a species/application not listed above to receive a full credit towards a future purchase.
Western Blot ELISA Immunocytochemistry/Immunofluorescence RNA Inhibition
This antibody reactivity against cell lysate and recombinant protein for WB. It has been used for RNAi Validation and ELISA. ICC/IF usage reported in scientific literature (PMID: 23644468).
Publications using H00001070-M01 in the following applications:
Zebrafish reactivity reported in scientific literature (PMID: 25344692).
Packaging, Storage & Formulations
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
PBS (pH 7.4)
Quality control test: Antibody Reactive Against Recombinant Protein.
This product is produced by and distributed for Abnova, a company based in Taiwan. Alternate Names for Centrin 3 Antibody (3E6.)
CDC31 yeast homolog CEN3centrin, EF-hand protein, 3 (CDC31 homolog, yeast) centrin, EF-hand protein, 3 (CDC31 yeast homolog) centrin, EF-hand protein, 3 centrin-3 EF-hand superfamily member MGC12502 MGC138245 Background
The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
for 1 year from date of receipt.
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Publications for Centrin 3 Antibody (H00001070-M01)(24)
We have publications tested in 2 confirmed species: Human, Zebrafish.
We have publications tested in 3 applications: ICC/IF, IP, WB.
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Show All 24 Publications.
Publications using H00001070-M01
Wang JT, Kong D, Hoerner CR et al. Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells. Elife. 2017 Sep 14 [PMID: 28906251] (ICC/IF, Human) ICC/IF
Pruikkonen S, Kallio MJ. Excess of a Rassf1-targeting microRNA, miR-193a-3p, perturbs cell division fidelity. Br J Cancer 2017 Apr 27 [PMID: 28449010]
Doobin DJ, Kemal S, Dantas TJ, Vallee RB Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages. Nat Commun 2016 Aug 24 [PMID: 27553190] (WB) WB
Tambe MB, Narvi E, Kallio M. Reduced levels of Dusp3/Vhr phosphatase impair normal spindle bipolarity in an Erk1/2 activity dependent manner. FEBS Letters 2016 Jul 16 [PMID: 27423135]
Chavali PL, Chandrasekaran G, Barr AR et al. A CEP215-HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer. Nat Commun 2016 Mar 18 [PMID: 26987684] (WB) WB
Sawant DB, Majumder S, Perkins JL et al. Centrin 3 is an inhibitor of centrosomal Mps1 and antagonizes Centrin 2 function. Mol. Biol. Cell 2015 Sep 09 [PMID: 26354417] (WB, IP, Human) WB, IP
Antonczak AK, Mullee LI, Wang Y et al. Opposing effects of pericentrin and microcephalin on the pericentriolar material regulate CHK1 activation in the DNA damage response. Oncogene. 2015 Jul 13 [PMID: 26165835]
Martin Ca, Ahmad I, Klingseisen A et al. Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. Nat. Genet. 2014 Oct 26 [PMID: 25344692] (ICC/IF, Zebrafish) ICC/IF
Kaczmarczyk A, Sullivan KF. CENP-W Plays a Role in Maintaining Bipolar Spindle Structure. PLoS One. 2014 Oct 15 [PMID: 25329824]
Lee Yin Loon, Sante Joshua, Comerci Colin J et al. Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function. Mol Biol Cell. 2014 Oct 01 [PMID: 25103236] (WB) WB
Show All 24 Publications.
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