CEACAM6/CD66c Antibody (B6.2) - BSA Free

Flow Cytometry: CEACAM6/CD66c Antibody (B6.2) [NBP3-09125] - Separation of neutrophil granulocytes stained anti-human CD66c (B6.2) purified antibody (concentration in sample 3 ug/ml, GAM APC, red-filled) from neutrophil granulocytes unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining).

Flow Cytometry: CEACAM6/CD66c Antibody (B6.2) [NBP3-09125] - Surface staining pattern of human peripheral whole blood stained using anti-human CD66c (B6.2) purified antibody (concentration in sample 3 ug/ml, GAM APC).

• Reactivity: Hu
• Applications: Flow, IP
• Clone: B6.2
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

CEACAM6/CD66c Antibody (B6.2) - BSA Free Summary

• Description: Novus Biologicals Mouse CEACAM6/CD66c Antibody (B6.2) - BSA Free (NBP3-09125) is a monoclonal antibody validated for use in Flow and IP. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Extracts from human breast carcinoma cells
• Specificity: The mouse monoclonal antibody B6.2 recognizes a conformationally dependent epitope of native CD66c, a GPI-anchored extracellular glycoprotein expressed on granulocytes and epithelial cells.
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: CEACAM6
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 3-12 ug/ml
  • Immunoprecipitation

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Phosphate buffered saline (PBS), pH 7.4
• Preservative: 15mM Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for CEACAM6/CD66c Antibody (B6.2) - BSA Free

• carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific crossreacting antigen)
• carcinoembryonic antigen-related cell adhesion molecule 6
• CD66c antigen
• CD66c
• CEACAM6
• CEACAM-6
• CEAL
• NCA
• NCACEAL
• Non-specific crossreacting antigen
• Normal cross-reacting antigen

Background

CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM 1, CEACAM 3-CEACAM 8) and 11 pregnancy-specific glycoprotein (PSG1-PSG11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. CEACAM 6 expression is strongly up-regulated already during early stages of adenocarcinoma formation e.g. in colon. The function of CEA family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CEACAM6