CEACAM6/CD66c Products

Description

CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM 1, CEACAM 3-CEACAM 8) and 11 pregnancy-specific glycoprotein (PSG1-PSG11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. CEACAM 6 expression is strongly up-regulated already during early stages of adenocarcinoma formation e.g. in colon. The function of CEA family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.

Bioinformatics

Product By Gene ID	4680
Alternate Names	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific crossreacting antigen) carcinoembryonic antigen-related cell adhesion molecule 6 CD66c antigen CD66c CEACAM6 CEACAM-6 CEAL NCA NCACEAL Non-specific crossreacting antigen Normal cross-reacting antigen

Research Areas for CEACAM6/CD66c

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Cancer