Cbl-c Antibody (OTI4E3) [Janelia Fluor® 669]

• Reactivity: Hu
• Applications: WB, Flow, CyTOF-ready
• Clone: OTI4E3
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 669

Cbl-c Antibody (OTI4E3) [Janelia Fluor® 669] Summary

• Immunogen: Human recombinant protein fragment corresponding to amino acids 244-474 of human CBLC(NP_036248) produced in HEK293T cell.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: CBLC
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Cbl-c Antibody (OTI4E3) [Janelia Fluor® 669]

• Cas-Br-M (murine) ecotropic retroviral transforming sequence c
• Cas-Br-M (murine) ectropic retroviral transforming sequence c
• CBL3
• CBL-3
• CBL-SL
• RING finger protein 57
• RNF57SH3-binding protein CBL-3
• SH3-binding protein CBL-C
• signal transduction protein CBL-C

Background

Cbl-c is also known as signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, and RING finger protein 57. Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl-c (a.k.a. Cbl-3) is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Cbl-c knock out mice show no obvious phenotype. Thus, the physiological role of Cbl-c is not known

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CBLC