Species: Hu
Applications: WB, Flow, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu
Applications: WB, Flow
Host: Mouse monoclonal
Species: Hu
Applications: WB, Flow
Host: Mouse monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
Cbl-c is also known as signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, and RING finger protein 57. Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl-c (a.k.a. Cbl-3) is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Cbl-c knock out mice show no obvious phenotype. Thus, the physiological role of Cbl-c is not known
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
23624 |
| Alternate Names |
- Cas-Br-M (murine) ecotropic retroviral transforming sequence c
- Cas-Br-M (murine) ectropic retroviral transforming sequence c
- CBL3
- CBL-3
- CBL-SL
- RING finger protein 57
- RNF57SH3-binding protein CBL-3
- SH3-binding protein CBL-C
- signal transduction protein CBL-C
|
Research Areas for Cbl-c
Find related products by research area and learn more about each of the different research areas below.
Stem Cell Markers
