Cathepsin V Antibody (182016) [Alexa Fluor® 350]

• Reactivity: Hu
• Applications: WB, IHC, IP
• Clone: 182016
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

Cathepsin V Antibody (182016) [Alexa Fluor® 350] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Cathepsin V
  Accession # O60911
• Specificity: Detects human Cathepsin V in direct ELISAs and Western blots. In Western blots, approximately 50% cross-reactivity with recombinant mouse (rm) Cathepsin H and recombinant human (rh) Cathepsin K is observed and no cross-reactivity with
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunoprecipitation
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Cathepsin V Antibody (182016) [Alexa Fluor® 350]

• Cathepsin L2
• Cathepsin U
• Cathepsin V
• CATL2
• CTSL2
• CTSUcathepsin L2, preproprotein
• CTSVMGC125957
• EC 3.4.22
• EC 3.4.22.43

Background

Cathepsin V (also known as Cathepsin L2 and U) is a cysteine protease of the papain family (1). It is expressed as a proenzyme in lysosomes, which can be autocatalytically converted to the mature form at pH 4.0 (2). Cathepsin V shows high amino acid identity with Cathepsin L (77% for the proenzymes and 80% for the mature enzymes) (3). However, Cathepsin V is specifically expressed in the thymus, testis, and corneal epithelium whereas Cathepsin L is expressed throughout the body.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.