Caspase-14 Antibody

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Caspase-14 Antibody Summary

Immunogen
A 15 residue synthetic peptide derived from N terminal domain of Human Caspase 14.
Localization
Cytoplasmic
Specificity
This reacts with Caspase 14 in cell extracts.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CASP14
Purity
Unpurified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:5000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
This antibody is useful for Immunohistochemistry-Paraffin and Western Blot.

Reactivity Notes

Reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Antiserum
Preservative
No Preservative
Purity
Unpurified

Alternate Names for Caspase-14 Antibody

  • apoptosis-related cysteine protease
  • CASP14
  • CASP-14
  • caspase 14, apoptosis-related cysteine peptidase
  • caspase 14, apoptosis-related cysteine protease
  • Caspase14
  • Caspase-14
  • EC 3.4.22.-
  • MGC119078
  • MGC119079
  • MICE

Background

Caspases are a family of cysteine proteases that play key roles in apoptosis. The precursor form of all caspaes is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunits, which associate into a2b2 tetramers to form the active enzyme. Caspase 14 also known as Mini ICE (MICE) is a member of the peptidase family C14 that has three potential isoforms. The pro form of Caspase 14 is approximately 29 kD. This caspase may be involved in the death receptor and granzyme B apoptotic pathways. Caspase 14 functions as downstream signal transducer of cell death that can be suppressed by retinoic acid. Caspase 14 becomes activated after granzyme B, Caspase 8, and Caspase 10 cleavage into large p18 and small p10 subunits. This caspase has been shown to associate with the large prodomain caspases, including Caspase 1, Caspase 2, Caspase 4, Caspase 8, and Caspase 10. Its high expression in embryonic tissues and limited expression in adult tissues suggests that it may have a role in ontogenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Blogs on Caspase-14.

Caspase 14 - A unique caspase needed for skin differentiation
Caspases are typically known for their role in cell death. However some caspases have recently been investigated for their function during cell proliferation and differentiation. Of these caspase-14 shows a unique expression pattern in the skin and...  Read full blog post.

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Bioinformatics

Gene Symbol CASP14
Entrez