Caspase-14 Antibody (868715) [Alexa Fluor® 350]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 868715
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

Caspase-14 Antibody (868715) [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human Caspase-14
  Ser2-Gln242
  Accession # P31944
• Specificity: Detects human Caspase-14 in direct ELISA and Western Blot.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Caspase-14 Antibody (868715) [Alexa Fluor® 350]

• apoptosis-related cysteine protease
• CASP14
• CASP-14
• caspase 14, apoptosis-related cysteine peptidase
• caspase 14, apoptosis-related cysteine protease
• Caspase14
• Caspase-14
• EC 3.4.22.-
• MGC119078
• MGC119079
• MICE

Background

Caspase-14 belongs to the evolutionarily conserved caspase family of cysteinyl aspartate-specific proteinases that frequently play a central role in apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce large and small subunits that dimerize to form an active enzyme. Caspase-14 is processed to form p19 and p10 subunits, but unlike many caspases, this activation is believed to be non-apoptotic. Expressed within hair follicles and sebaceous glands in the epidermis, Caspase-14 processing is implicated in terminal keratinocyte differentiation and cornification. Caspase-14 expression may also protect against psoriasis and epidermal UVB photodamage. Full-length human Caspase-14 is 242 amino acids (aa) in length, and shares 71% and 72% aa sequence identity with mouse and rat Caspase-14, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.