Carboxypeptidase E/CPE Antibody (420709) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB, IP
• Clone: 420709
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

Carboxypeptidase E/CPE Antibody (420709) [Alexa Fluor® 750] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Carboxypeptidase E/CPE
  Arg42-Ser453
  Accession # P16870
• Specificity: Detects human Carboxypeptidase E/CPE in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) CPA1, rhCPA2, rhCPB1, or recombinant mouse CPA4 is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Carboxypeptidase E/CPE Antibody (420709) [Alexa Fluor® 750]

• Carboxypeptidase E
• Carboxypeptidase H
• CPE
• CPH
• CPH-1
• EC 3.4.17
• EC 3.4.17.10
• Enkephalin convertase
• Prohormone-processing carboxypeptidase

Background

Carboxypeptidase E (CPE) is a peripheral membrane protein that cleaves C-terminal amino acid residues and is involved in the processing of numerous peptide hormones and neurotransmitters. CPE knockout mice live but become obese due to impaired glucose clearance and insulin resistance. The CPE precursor includes a signal peptide (aa 1‑25), a propeptide (aa 26‑42) and a mature chain (aa 43‑476). The amino acid sequence of human CPE is 99.8%, 96.6%, 96.3%, and 90.2% identical to that of chimpanzee, mouse, dog and chicken.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.