Calreticulin-2/CALR3 Antibody (321007) [Alexa Fluor™ Plus 680]

• Reactivity: Hu
• Clone: 321007
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 680

Calreticulin-2/CALR3 Antibody (321007) [Alexa Fluor™ Plus 680] Summary

• Specificity: Detects human Calreticulin-2 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human Calreticulin is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Calreticulin-2/CALR3 Antibody (321007) [Alexa Fluor™ Plus 680]

• CALR3
• calreticulin 2
• calreticulin 3
• Calreticulin2
• Calreticulin-2
• calreticulin-3
• cancer/testis antigen 93
• Crt2
• CRT2calreticulin-2
• CT93
• FLJ25355
• MGC26577

Background

Calreticulin-2 is a soluble lectin-like molecule that participates in the protein folding and quality control cycle in the endoplasmic reticulum (ER) lumen. Mature human Calreticulin-2 has a 178 amino acid N-terminal globular domain, a 97 aa central P-domain, and a 90 aa C-terminal domain. The globular domain shows lectin activity, the P-domain binds one Ca⁺⁺ ion with high affinity, and the C-terminus binds Ca⁺⁺ and contains an RNEL ER retention motif. The amino acid sequence of Calreticulin‑2 is 84%, 83% and 87% identical to that of mouse, bovine and canine Calreticulin‑2, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.