CACNB2 Antibody

ELISA: CACNB2 Antibody [30260002]

Product Discontinued

CACNB2 Antibody Summary

• Immunogen: This antibody is specific for the C Terminus Region of the target protein.
• Specificity: This product is specific for Human CACNB2.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CACNB2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
• Application Notes: This antibody is useful in ELISA.

Reactivity Notes

Human.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Notes

Manufactured by SDIX's proprietary Genomic Antibody Technology™. GAT FAQs.

Alternate Names for CACNB2 Antibody

• CAB2
• CACNB2
• CACNLB2
• Calcium channel voltage-dependent subunit beta 2
• calcium channel, voltage-dependent, beta 2 subunit
• CAVB2
• FLJ23743
• Lambert-Eaton myasthenic syndrome antigen B
• myasthenic (Lambert-Eaton) syndrome antigen B
• MYSB
• voltage-dependent L-type calcium channel subunit beta-2

Background

Function: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.; Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRS4). BRS4 is a heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.; Subcellular location: Cell membrane sarcolemma; Peripheral membrane protein; Cytoplasmic side; Tissue specificity: Expressed in all tissues.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CACNB2 Antibody (30260002)(2)

Publications using 30260002

• Garrison C, Lastwika K, Zhang Y et al. Proteomic Analysis, Immune Dysregulation, and Pathway Interconnections With Obesity J Proteome Res. 2017-01-06 [PMID: 27769113] (MiAr)
  
  Details:
  Analysis is performed on plasma proteomic data to identify how obesity can alter pathways and to highlight the risk factor for disease in subjects with a high body mass index.
• Rho JH, Lampe PD. High-throughput screening for native autoantigen-autoantibody complexes using antibody microarrays J Proteome Res. 2013-05-03 [PMID: 23541305] (MiAr)
  
  Details:
  A novel method using antibody microarrays is used to detect autoantibody-antigen complexes that can potentially be useful for detection and characterization of diseases.

Bioinformatics

• Gene Symbol: CACNB2
• Entrez:
  • 783(Human)
• Uniprot:
  • Q08289(Human)