CABC1 Antibody (7G1)

Western Blot: CABC1 Antibody (7G1) [H00056997-M04A] - Analysis of CABC1 expression in Hela S3 NE (Cat # L013V3).

Product Discontinued

CABC1 Antibody (7G1) Summary

• Immunogen: CABC1 (AAH05171, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.MAAILGDTIMVAKGLVKLTQAAVETHLQHLGIGGELIMAARALQSTAVEQIGMFLGKVQGQDKHEEYFAENFGGPEGEFHFSVPHAAGASTDFSSASAPD
• Specificity: CABC1 - chaperone, ABC1 activity of bc1 complex like (S. pombe) (7G1)
• Isotype: IgM Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: COQ8A
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot 1:500
• Application Notes: Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Ascites
• Preservative: No Preservative
• Purity: Unpurified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for CABC1 Antibody (7G1)

• aarF domain containing kinase 3
• chaperone, ABC1 activity of bc1 complex homolog (S. pombe)
• chaperone, ABC1 activity of bc1 complex homolog
• chaperone, ABC1 activity of bc1 complex like (S. pombe)
• chaperone-ABC1 (activity of bc1 complex, S.pombe)-like
• Chaperone-ABC1-like
• coenzyme Q8 homolog
• EC 2.7.11
• EC 2.7.11.-
• MGC4849
• mitochondrial
• SCAR9

Background

This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CABC1 Antibody (H00056997-M04A)(4)

Publications using H00056997-M04A

• Rodriguez-Hidalgo M, Luna-Sanchez M, Hidalgo-Gutierrez A et al. Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis. Sci Rep 2018-09-18 [PMID: 30228311]
• Barca E, Kleiner G, Tang G et al. Decreased Coenzyme Q10 Levels in Multiple System Atrophy Cerebellum. J Neuropathol Exp Neurol 2016-05-27 [PMID: 27235405]
• Luna-Sanchez M, Diaz-Casado E, Barca E et al. The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene. EMBO Mol Med. 2015-03-23 [PMID: 25802402]
• OConnell KE, Guo W, Serra C et al. The effects of an ActRIIb receptor Fc fusion protein ligand trap in juvenile simian immunodeficiency virus-infected rhesus macaques. FASEB J. 2014-12-02 [PMID: 25466897]

Bioinformatics

• Gene Symbol: COQ8A
• Entrez:
  • 56997(Human)
• Uniprot:
  • AAH05171(Human)