BCAM/CD239 Antibody [Alexa Fluor® 405]

• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 405

BCAM/CD239 Antibody [Alexa Fluor® 405] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse BCAM
  Met1-Ala541
  Accession # Q9R069
• Specificity: Detects mouse and rat BCAM in Western blots. In direct ELISAs, less than 50% cross-reactivity with recombinant human BCAM is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Mouse BCAM (Basal cell adhesion molecule, B-CAM cell surface glycoprotein,Lutheran antigen, and CD239) is a 70-90 kDa membrane glycoprotein. BCAM has wide tissue distribution and is expressed on erythrocytes, the endothelium of blood vessels and on the basal layer of cells in the epithelia. The expression of BCAM in normal tissues is higher in fetal versus adult tissues. BCAM expression is also upregulated in activated keratinocytes and following malignant transformation in some cell types in vivo and in vitro. BCAM has been shown to be an adhesion molecule that binds laminin, a basement membrane protein involved in cell differentiation, adhesion, migration and proliferation. Over aa 1-541, mouse BCAM is 91% identical to rat BCAM.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.