BCAM/CD239 Antibody (87207) [Alexa Fluor® 594] Summary
Mouse myeloma cell line NS0-derived recombinant human BCAM
Accession # CAA58449
Detects human BCAM in ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) ALCAM, rhEpCAM, recombinant mouse (rm) MAdCAM-1, rhMCAM, rhNCAM-L1, rmOCAM, or rmTROP‑2 is observed.
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Flow Cytometry 0.25-1 ug/10^6 cells
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.
Packaging, Storage & Formulations
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
0.09% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for BCAM/CD239 Antibody (87207) [Alexa Fluor® 594]
- antigen identified by monoclonal F8
- Auberger B antigen
- basal cell adhesion molecule (Lu and Au blood groups)
- basal cell adhesion molecule (Lutheran blood group)
- basal cell adhesion molecule
- B-CAM cell surface glycoprotein
- B-cell adhesion molecule
- CD239 antigen
- F8/G253 antigen
- glycoprotein 95kDa
- Lutheran antigen
- Lutheran blood group (Auberger b antigen included)
- Lutheran blood group glycoprotein
Basal-Cell Adhesion Molecule (BCAM) and Lutheran blood group glycoprotein (LU) are two alternatively spliced variants of a single immunoglobulin superfamily (IgSF) protein that differ in the length of their cytoplasmic tails. BCAM cDNA encodes a 628 amino acid (aa) residues precursor protein with a putative 31 aa signal peptide, a 597 aa extracellular domain containing three C2 type and two V-type Ig-like domains, a 21 aa transmembrane domain, and a 19 aa cytoplasmic domain. Compared to the 40 aa cytoplasmic domain present in LU, the BCAM cytoplasmic tail lacks the putative Src homology 3 (SH3) binding site that may be involved in mediating intracellular signaling. BCAM/LU has wide tissue distribution and is expressed on erythrocytes, the endothelium of blood vessels and on the basal layer of cells in the epithelia. The expression of BCAM/LU in normal tissues is higher in fetal versus adult tissues. BCAM/LU expression is also upregulated in sickle cell disease red blood cells, in activated keratinocytes and following malignant transformation in some cell types in vivo and in vitro. BCAM/LU has been shown to be an adhesion molecule that binds laminin, a basement membrane protein involved in cell differentiation, adhesion, migration and proliferation.
- Campbell, I.G. et al. (1994) Cancer Research 54:5761.
- Parsons, S.F. et al. (1995) Proc. Natl., Acad. Sci. USA, 92:5496.
- Udani, M. et al. (1998) 101:2550.
- Schon, M. et al. (2000) J. Invest. Dermatol, 115:1047.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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