ATF6 Antibody [DyLight 650]


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Product Details

Reactivity HuSpecies Glossary
Applications ICC/IF
Please see the vial label for concentration. If unlisted please contact technical services.

ATF6 Antibody [DyLight 650] Summary

A genomic peptide made to an internal region of the human ATF6 protein (within residues 200-350). [Swiss-Prot P18850]
Endoplasmic reticulum membrane, nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C in the dark.
DyLight 650
DyLight 650 (A=652, E=672)
50mM Sodium Borate
0.05% Sodium Azide
Immunogen affinity purified


  • Immunocytochemistry/Immunofluorescence 1:100
Application Notes
This ATF6 antibody is useful for Immunocytochemistry/Immunofluorescence.

Reactivity Notes


Alternate Names for ATF6 Antibody [DyLight 650]

  • Activating transcription factor 6 alpha
  • activating transcription factor 6
  • ATF6A
  • ATF6-alpha
  • cAMP-dependent transcription factor ATF-6 alpha
  • cyclic AMP-dependent transcription factor ATF-6 alpha


Endoplasmic reticulum stress results in protein folding irregularities and proteolytic abberations. ER stress is mediated in part by the activating transcription factor (ATF6). ATF6 is a signal transducer that prohibits phosphorylation of certain proteins, like the insulin receptor, and protects overactive responses to ER stress. This ultimately mediates apoptosis through mitochondrial cellular signaling. Influenza infections are known to affect ER stress in lung endothelial cells, partially mediated by ATF6 activity. This protein is also being investigated for potential optimization of recovery efforts, following traumatic injury, especially in spinal cord and brain.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

ICC/IF Video Protocol

FAQs for ATF6 Antibody (NBP1-75478C). (Showing 1 - 1 of 1 FAQ).

  1. We are looking for an antibody specific to ATF6 alpha that will not cross-react with ATF6 beta. Would you please help confirm if any of the following are ATF6 alpha specific antibodies: NBP1-40256, NBP1-77251, NBP1-76675 & NBP1-41439?
    • The antibodies NBP1-77251 and NBP1-76675 are specific to ATF6 alpha and should not cross-react with ATF6 beta.

Secondary Antibodies


Isotype Controls

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Research Areas for ATF6 Antibody (NBP1-75478C)

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Blogs on ATF6.

ATF6 - monitoring and regulating protein folding under cellular stress
During times of cellular stress overloading of the protein folding machinery leads to the accumulation of incorrectly folded proteins. This triggers the unfolded protein response (UPR) in order to try to reestablish homeostasis or, if this fails, t...  Read full blog post.

ATF6 - a key target in alcohol-induced fatty liver disease?
Untitled DocumentThe ATF6 endoplasmic reticulum (ER) stress-regulated transcription factor is constitutively expressed and plays a central role in the mammalian unfolded protein response (UPR). This fundamental pathway is responsibl...  Read full blog post.

A Key to Fight Stress: ATF6
The protein ATF6 is a constitutively expressed transcription factor that is a key mediator of the unfolded protein response (UPR) that allows mammalian cells to maintain cellular homeostasis under conditions of environmental and physiological stress....  Read full blog post.

Contact Information

Product PDFs


Gene Symbol ATF6

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